electrochemical behaviour of nifedipine and nitrendipine in chloroform and chloroform-isopropanol mixture

Authors

s. mehdi golabi

massoud fazli

yousef rastegar mirzaei

abstract

the electrochemical behavior of nifedipine (i), nitrendipine(ii) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (ppc) as supporting electrolyte. it has been shown that i and ii undergo in a 4e, 4h+ irreversible reduction reaction, while the reduction product, phenylhydroxylamine, is oxidized in a 2e, 2h+ reversible process to an unstable nitrosophenyl compound. photodegradation of i and ii by sunlight produces a nitrosophenyl derivative which is reversibly reduced to the corresponding unstable phenylhydroxylamine. no significant change is observed in electrochemical properties of drugs by passing from chloroform to chloroform-isopropanol mixture. the possibility of analysis of i and ii by dp polarography is also verified.

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Journal title:
iranian journal of chemistry and chemical engineering (ijcce)

Publisher: iranian institute of research and development in chemical industries (irdci)-acecr

ISSN 1021-9986

volume 17

issue 1 1998

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